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MRI brain volume analysis using NeuroQuant® software

NeuroQuant® is an exciting development for uncovering evidence of brain injury in our patients with mild to moderate traumatic brain injury. Most patients with mild to moderate traumatic brain injury (TBI) have normal CT scans and MRI scans. For years, advances in structural brain imaging have promised to remedy this situation. Finally, the promises of the research laboratory are readily available for everyday patients in the clinic.

NeuroQuant® is a software program approved by the FDA for measuring brain MRI volume.  NeuroQuant® automatically identifies several MRI brain regions and measures the volume of each. These data are then compared to MRI data from normal control subjects. In addition to the NeuroQuant® standard report (which measures 11 brain regions but compares only 3 regions to normal controls) we have extended the utility of the test by comparing all 11 regions to normal controls, and by examining longitudinal change (obtaining 2 MRIs in the same patient, several months apart, and looking for progressive atrophy).  

Click here to read an article about evidence supporting the use of NeuroQuant® in patients with traumatic brain injury.

Since June 2010, we have been applying this technique to patients with traumatic brain injury (TBI). In our group comparisons of patients vs. normal controls, we found that NeuroQuant® was useful for identifying areas of brain atrophy in patients with mild to moderate TBI. Analyses of individual patients using NeuroQuant® has shown that most patients had evidence of brain atrophy; in contrast, only a small minority of patients had brain atrophy based on traditional (visual inspection-based) interpretation by the radiologist. In other words, NeuroQuant® has a much higher “hit rate” than traditional interpretation.

Dr. Ross and colleagues have had scientific abstracts accepted for presentation at national meetings (see Dr. Ross’s CV).  


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